Theme I: A multi-omics system biology approach to identify disease control mechanisms in HIV-1 Elite Controller
The purpose of this research program is through translational research integrating the multi-omics techniques and the clinical data to understand the disease control mechanism in a group of HIV-1 positive individuals, who control viral replication and restrained progression to AIDS, without any antiretroviral therapy for a longer duration of time (Elite controller). In a systemic way, we apply the molecular data-first approach (using Genomics, transcriptomics, proteomics and metabolomics) classifies persistent genetic variants or expression patterns in order to reduce host influenced heterogeneity followed by the phenotypic profiling, virological and immunological characterizations of the disease control mechanism. This understanding of the unique gene expression and immunological characteristics of EC will predict a frame of reference for what may be required in clinical intervention strategies to induce immune control of HIV-1 and the future development of functional HIV-cure.
Theme II: Mechanisms of drug resistance dynamics and efficacy of newly emerging long acting antiretroviral compounds in diverse HIV-1 subtypes
The prime research question in this program is to achieve the maximum efficacy of the newly emerging antiretroviral compounds (reverse transcriptase inhibitors, integrase inhibitor and protease inhibitor) understanding the viral suppression potentials, mechanisms of resistance and viral persistence across diverse subtypes. The consequent optimization of the use of these drugs could potentially lead to that they will become the drug-of-choice in globally including the low- and middle- income countries. The studies run as a part of large multi-disciplinary expert project in the field of molecular biology, virology, structural protein modelling and biochemistry, high throughput genomics, evolutionary dynamics and clinical science.
Theme III. Molecular epidemiological studies of HIV-1 subtypes in Sweden